Comparative efficacy of five brands of Arthemeter Combination Therapy (ACTS) purchased in Ekiti State, Nigeria

Malaria is one of the most severe public health problems and a leading cause morbidity mortality where children pregnant women are affected groups. This may be as result resistant malaria parasites which mostly traceable to drug adulteration. In this study, Plasmodium berghei NK65, rodent parasite was used model organism simulate human parasite. The efficacy five brands arthemeter combination therapies (ACTs) purchased from pharmacy stores in Ekiti state were evaluated. drugs coded Art-Ar, Art-Ph, Art-Ki, Art- Na, Art-Gy respectively. Twenty-one mice constituted into seven different groups three mice. Each mouse inoculated inter-peritoneally with NK65 left for 7days manifest. prepared solution administered on orally 10 days, while remaining positive negative control One given chloroquine (positive) other normal saline (negative). antimalarial determined by examining their influence increase or decrease number (parasitemia level). Giemsa stained thin blood smears tails assess parasitemia level clearance rate. Results show that average rates 14.1, 40.6, 25.3, 44.9 27.9 Arthemeter Na All significantly cleared all within 7-9days treatment, shows adulterated not presently community studied. Therefore, therapy recommended choice treatment fever State.